Unexplained infertility is a very frustrating ‘diagnosis’ for so many couples (and their clinics!). On one hand, couples are happy that there is nothing obviously broken in either of them but on the other hand it just makes it all the more frustrating that there is nothing they can fix!
For 80% of the couples diagnosed with unexplained infertility – we have found a cause!
Our sensitive SpermComet™ test can detect clinically significant DNA damage in their sperm

www.sciencedirect.com/science/article/pii/S1472648312005901
Male Infertility
When we think about infertility, especially in these couples, very often we focus on the female but in fact male infertility contributes to nearly 50% of all infertility cases. Sperm DNA damage has been identified as a major contributor to male infertility and linked to problems with all the early fertility check points and even to the short and long term health of the baby.
Sperm DNA damage
Much recent research shows that sperm quality is not as good as it was. This is one of the reasons for increasing numbers of couples seeking fertility treatment all around Europe. There are many lifestyle causes for this like smoking, poor diet and environmental pollutants. All of these produce free radicals that can damage sperm DNA.

Sperm DNA damage can lead to:
· Fewer eggs being fertilized
· Poor embryo development
· Lower pregnancy rates
· More miscarriages

What if the semen analysis is normal? Can testing for sperm DNA damage help decide what treatment is best for you?
Yes. Recent research shows that that there is little connection between a traditional semen analysis result and sperm DNA damage So, even if a sperm count is normal, the male may be infertile from sperm DNA damage. Measuring sperm DNA quality is much more sensitive than a semen analysis test at detecting subtle problems.

How Sperm DNA testing can guide to the right diagnosis and treatment choice for unexplained couples .
If the sperm have more than 25% damage: The chances of intrauterine insemination (IUI) succeeding are very low.
If the sperm have more than 50% damage, there is very little chance of a take home baby even with IVF. The good news is that now we have a diagnosis, we can choose fertility treatment more suited to the needs of these couples with idiopathic infertility.